Atypical periodic paralysis and myalgia

Atypical periodic paralysis and myalgia

OBJECTIVE To characterize the phenotype of patients with symptoms of periodic paralysis (PP) and ryanodine receptor (RYR1) gene mutations. METHODS Cases with a possible diagnosis of PP but additional clinicopathologic findings previously associated with RYR1-related disorders were referred for a tertiary neuromuscular clinical assessment in which they underwent detailed clinical evaluation, i...

An atypical case of periodic paralysis.

Familial Periodic Paralysis

Familial periodic paralysis is a malady usually characterized by (1) recurrent flaccid muscular paralysis, (2) history of the disease in other members of the family, (3) depression of the level of potassium ions in the blood serum during an episode of paresis, (4) impairment of electrical excitability of the musculature, (5) impairment of deep reflexes, (6) retention of consciousness without al...

Hyperthyroid hypokalemic periodic paralysis

Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like pr...

Thyrotoxic periodic paralysis.